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KMID : 0385019940100010045
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Korean Journal of Laboratory Animal Science
1994 Volume.10 No. 1 p.45 ~ p.50
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Studies on the Antigenicity of Hepatitis B Vaccine Derived from CHO Cell in Guinea Pig and Rat
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김희철/Kim, Hee Chul
황규계/계동범/최중호/Hwang, Kyu Kye/Kye, Dong Bum/Choi, Chung Ho
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Abstract
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Hepatitis B vaccine, KGCG92-3, derived from Chinese hamster ovary(CHO) cell was evaluated for antigenicity through Active Systemic Anaphylaxis(ASA) in guinea pig and Passive Cutaneous Anaphylaxis(PCA) in rat.
In the study of ASA of guniea pig, KGCC-92-3 did not induce any significant symptoms relating anaphylatic shock and was almost asymptomic at both level of low dose and high dose. Also in the study of PCA of rat using anti-guinea pig serum to KGCC-92-3 at both level of low dose and high dose, KGCC-92-3 did not induce blue coloring reaction reflecting specific antibody IgE which generally has been accepted that it takes part in type j hypersensitivity reacting strongly in human.
Therefore, it was observed that KGCC-92-3 would cause no effects on anaphylatic shock.
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KEYWORD
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